Improvement in health-related quality of life with Botulinum toxin A injection in acquired superior oblique palsy

Purpose This study aimed to investigate the outcomes of Botulinum toxin A (BTA) injection into inferior oblique (IO) muscle for management unilateral acute acquired superior palsy (SOP) and evaluate changes in health-related quality life post-injection using Adult Strabismus-20 (AS-20) questionnaire. Methods prospective cohort was performed patients with SOP who received BTA injections. Four units were injected ipsilateral IO muscle. Ocular examinations pre-and post-injection, including alignment, ocular movement, cyclotorsion deviation. The patients’ AS-20 questionnaire scores analyzed. Results total 21 included. initial median vertical deviation 5 PD (range 1–16), which improved 0 0–10) at both 1 6 months ( p < 0.001 0.001, respectively). torsional 7° 2–18) baseline resolved degrees −3–5) 1-month 0° −2–7) 6-month follow-up There significant increases overall score (OAS), psychosocial subscale (PSS), functional (FSS) from values = respectively) (all 0.001). Conclusion Injecting successfully deviations significantly quality-of-life scores. Our findings show that treatment, as an early treatment SOP, can help by improving their life.